Cab Drivers Experience Neurogenesis in Posterior Hippocampi, but Lose Performance For Other Tasks

by Neurofreak on December 16, 2011

Three to four years later, however, the researchers found an increase in gray matter in the posterior hippocampi, or the back part of the hippocampus, among the 39 trainees who ultimately qualified as taxi drivers. This change was not observed in the non-taxi drivers or trainees who had failed the exams. [...]

Qualified taxi drivers showed better memory performance for London-based information during the follow-up testing than controls or those who failed the test; however, they displayed “surprisingly poorer learning and memory for certain types of new visual information,” compared with controls, the researchers write online today in the journal Current Biology, “suggesting there might be a price to pay for the acquisition of their spatial knowledge.” (via.)

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Cannabinoid receptors involved in placebo mediated pain relief

by Neurofreak on October 8, 2011

Cannabinoid receptors involved in placebo analgesia.

Placebo analgesia is mediated by both opioid and nonopioid mechanisms, but so far nothing is known about the nonopioid component. Here we show that the specific CB1 cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (rimonabant or SR141716) blocks nonopioid placebo analgesic responses but has no effect on opioid placebo responses. These findings suggest that the endocannabinoid system has a pivotal role in placebo analgesia in some circumstances when the opioid system is not involved. (via

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Posterior Medial Prefrontal Cortex Modulating Conformity

September 4, 2011

When Transcranial Electromagnetic Stimulation (TMS) was used to inhibit the activity of the neurons in the posterior medial frontal cortex, the participants did not change their ratings of the photographs so they were more in line with the rest of the group. Dr Klucharev believes this part of the brain is responsible for generating an [...]

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To Science, Morality isn’t Special

August 4, 2011

Nothing Either Good Or Bad? You’re a 10-year-old girl in Africa, lying nervously on your back with your lower body fully exposed. You don’t know why, but the grown-ups nearby keep assuring you that the tradition they’re about to carry out is to prevent you from becoming one of those immoral outcasts. They are concerned [...]

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The Hard Problem of Consciousness

July 26, 2011

You’re lying on a sandy beach on a hot sunny afternoon, enjoying a few hours of much needed laziness. As you open your eyes and confront the vastness of the ocean in front of you, light of 600nm wavelength hits your retina, kindling an impossibly long cascade of events in your brain: a molecule called [...]

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CB1 Receptor Knockouts Have An Accelerated Cognitive Decline

July 13, 2011

Study finds that CB1 receptor knockout mice have increased brain inflammation, which leads to earlier cognitive decline. Brain aging is associated with cognitive decline that is accompanied by progressive neuroinflammatory changes. The endocannabinoid system (ECS) is involved in the regulation of glial activity and influences the progression of age-related learning and memory deficits. Mice lacking [...]

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Learning, Gamma Rhythm, and Speed

June 27, 2011

Rhythms in the brain that are associated with learning become stronger as the body moves faster, UCLA neurophysicists report in a new study. The research team, led by professor Mayank Mehta, used specialized microelectrodes to monitor an electrical signal known as the gamma rhythm in the brains of mice. This signal is typically produced in [...]

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Conquering All Mysteries By 100 Billion Rules and Lines and Brain Cells

June 23, 2011

The starry heavens above and the moral law within — these were the two things that Immanuel Kant claimed were immune to scientific investigation. Equally untouchable was the vague abstraction known as consciousness. That was in the 1700s. This book-length book of a post will be split into two parts, each covering the hot buttons of [...]

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The Illusion of Free Will and What it Means for the Justice System

June 17, 2011

Excellent quote from a really good article by David Eagleman: Instead of debating culpability, we should focus on what to do, moving forward, with an accused lawbreaker. I suggest that the legal system has to become forward-looking, primarily because it can no longer hope to do otherwise. As science complicates the question of culpability, our [...]

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The Miracle of Neuroscience: A Life of Grad School, Research, Science Literacy, and What These Really Mean

June 1, 2011

Scientists are bipolar masochists in white coats. And we are okay with that. This post will be somewhat atypical. No science-heavy references, no hard data, no hypotheses — nothing new. It’ll be just one general and optimistic story for the non-specialist, a story and opinion that celebrates neuroscience to the bone. Imagine taking a scalpel [...]

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