Stroke damage control with caffeinol (caffeine and alcohol/ethanol)

A study found a special cocktail of caffeine and ethanol actually reduced brain damage in a rat model of ischemic stroke up to 80% so long as it was administered within three hours of the stroke. Now the study is being run on humans, check it out:

In experimental drug delivering the potency of two cups of strong coffee and a mixed drink has been shown to limit stroke-induced brain damage in animals. Now, this agent has been demonstrated to be safe in a small pilot study of ischemic stroke patients reported in today’s rapid access issue of Stroke: Journal of the American Heart Association. [...]

Those studies “demonstrated that the combination of caffeine and ethanol may reduce the amount of damage after stroke. Neither caffeine or alcohol offered protection alone, but the combination was protective,” says senior author James C. Grotta, M.D., professor of neurology and director of the stroke program, University of Texas-Houston Medical School, Houston, Texas. [...]

Researchers administered the combination to 23 stroke patients (16 women, average age 71). The patients represented a diverse racial mix: nine white, nine black, four Hispanic and one Asian.

“Our goal was to see if we could safely achieve the same blood levels of caffeinol that we achieved in our animal studies,” he says. “We discovered that we could use even lower doses than we used in the animal studies and achieve the blood levels that were neuroprotective in animals.”

Moreover caffeinol, which is given by infusion, can be safely administered to patients who are also receiving clot-busting treatment with tissue plasminogen activator (tPA). Eight patients received both caffeinol and tPA. One patient with a very severe stroke who received caffeinol and tPA suffered an intracerebral hemorrhage (bleeding within the brain), but Grotta says an independent safety officer concluded it was not related to caffeinol.

The first set of four patients were given low-dose caffeinol (caffeine 6 milligrams per kilogram plus ethanol 0.2 grams per kilogram). That dose did not achieve the target blood level, so the dose was increased (8 mg/kg caffeine and 0.4 g/kg ethanol) in the next group of 19 patients. That achieved target blood levels, he says. However, Grotta cautioned that the ethanol level may need further adjustment because a patient with a history of heart disease developed reversible heart failure at that dose level. It is unclear how caffeinol works to protect the brain, but it is being studied. (via.)

So they haven’t worked out all the kinks just yet, but all-in-all it sounds like they’re on the path to some good things there.

Caffeine increasing susceptibility to persuasion?

Before the attempt to change their minds, half the participants were given moderate doses of caffeine, while the other half took a placebo. Both groups were double-blinded so that neither the researchers nor the participants knew who had taken what. Then they were given six stories to read which argued against euthanasia.

When asked afterwards for their attitude to voluntary euthanasia, those who had drunk caffeine were more influenced by the persuasive message than those who’d had the placebo.

On top of this, participants were asked about their attitude towards abortion which, the experimenters guessed, would be indirectly influenced, since someone who disapproves of euthanasia is also likely to disapprove of abortion. And this is exactly what they found. The persuasive message had spread to a related idea and the effect was strongest amongst those who had consumed caffeine.

Read more of the original article to find out the “why”…