Anabolic steroids, depression, BDNF & morning corticosterone levels


Abuse of anabolic androgenic steroids (AASs) is frequently associated with changes in mood, including depression. [...] We used male adult rats injected for 4 weeks with either nandrolone or stanozolol at daily doses (5 mg/kg, s.c.) that are considered equivalent to those abused by humans [...] AAS treatment reduced levels of brain-derived neurotrophic factor in the hippocampus and prefrontal cortex, reduced the expression of low-affinity glucocorticoid receptors in the hippocampus, and increased morning trough basal plasma corticosterone levels. All these changes have been related to the pathophysiology of major depressive disorder. Accordingly, rats treated with nandrolone or stanozolol showed an increased immobility time in the forced swim test, which is widely used for the screening of antidepressant drugs. All effects produced by AASs were prevented by co-administration with the classical antidepressant, chlorimipramine. (via.)


Exercise reverses anxiety phenotype in rats


Exercise can ameliorate anxiety and depression-like behaviours induced by an adverse early-life environment by altering the chemical composition in the hippocampus – the part of the brain that regulates stress response, researchers from UNSW have found. [...]

“What’s exciting about this is that we are able to reverse a behavioural deficit that was caused by a traumatic event early in life, simply through exercise,” said Professor of Pharmacology Margaret Morris, who will present the findings this week at the International Congress of Obesity in Stockholm.

In the study, rats were divided into groups and either isolated from their mothers for controlled periods of time to induce stress or given normal maternal contact. Half were given access to a running wheel.

In addition to being more anxious, animals that were subjected to stress early in life had higher levels of stress hormones and fewer steroid receptors in the part of the brain controlling behaviour.

“Both the anxious behaviour and the levels of hormones in these rats were reversed with access to the exercise wheel,” Professor Morris said.

“We know that exercise can elevate mood, but here we are seeing chemical changes that may underpin this improvement. One of these is increases in brain-derived neurotrophic factor (BDNF), which helps nerve cells grow. (via.)

In other news…
Morphine found to decrease testosterone in the brain, as well as liver, and testis. Which is interesting in light of the fact that a stressed/anxious phenotype of rat would have fewer steroid receptors in their brain.