Kleine-Levin Syndrome: Sleep 10 days at a time? You might have it.


“I was hallucinating and after that I don’t remember anything. All of a sudden it just went blank and I just slept for 10 days. I woke up and I was fine again.” [...]

“I was hallucinating and after that I don’t remember anything. All of a sudden it just went blank and I just slept for 10 days. I woke up and I was fine again.” [...]

Louisa is unusual as KLS usually affects teenage boys, who can also exhibit hypersexuality and inappropriate behaviour.

As well as excessive sleeping, symptoms include behaviour changes, irritability, feeling in a dream-like state and binge eating, symptoms that can be mistaken for normal teenage behaviour. [...]

The change in behaviour before and during a sleep episode is one of the most upsetting things for Louisa’s parents, who take it in turns to remain with her. Doctors have told the family it’s crucial to wake Louisa once a day to feed her and get her to the bathroom.

But Lottie admits it can take a while to get her to come round. “I’ve tried before to literally force her to wake up but she just starts swearing and gets so agitated and aggressive.” [...]

Many sufferers have abnormalities in their temporal lobe, the area of the brain involved in behaviour and memory. A scan of Louisa’s brain function revealed she does have abnormalities in her frontal lobe but there are no signs that this has affected her behaviour or memory. (via.)


BDNF, hyperlexia, hypergraphia, seizures…


Just some loosely connected neuro-things I wanted to save somewhere.

  • Notably without citation, Wikipedia claims BDNF is also expressed in the retina, the central nervous system, motor neurons, the kidneys, and the prostate (aside from just the hippocampus and cerebral cortex). (via.)
  • BDNF knockingout in mice affects coordination, balance, hearing, taste, and breathing. “Knockout mice also exhibit cerebellar abnormalities and an increase in the number of sympathetic neurons.” (via.)
  • BDNF is increased by prolonged seizures, and important to GABA pathways. (via.)
  • Hypergraphia, a condition which afflicts individuals with a compulsive desire to write, is associated with temporal lobe epilepsy… and quite a few interesting characters have had it. (via.)
  • Hyperlexia, the extreme variety of a compulsion to read, may be caused by a “cerebral infarction in the left anterior cingulate cortex and corpus callosum.” (via.)
  • Temporal lobe epileptics are often hyposexual. (via.)