What’s BDNF & substance p got to do with eczema?

Per Wikipedia BDNF is…

BDNF acts on certain neurons of the central nervous system and the peripheral nervous system, helping to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses.

So I ran across this little interesting tidbit that I’ll want to follow up on later, if I happen to remember to. That is that apparently elevated levels of BDNF and Substance P (involved in nociception/pain perception) is involved in eczema? Per Substance P’s Wikipedia:

High levels of BDNF and Substance P have been found associated with increased itching in eczema.[27][28]

Interestingly also, apparently naked mole rats lack substance p altogether.

Totally unrelated, but also unusual… BDNF is found to be increased after prolonged seizure activity.