Cannabinoid receptors involved in placebo mediated pain relief


Cannabinoid receptors involved in placebo analgesia.

Placebo analgesia is mediated by both opioid and nonopioid mechanisms, but so far nothing is known about the nonopioid component. Here we show that the specific CB1 cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (rimonabant or SR141716) blocks nonopioid placebo analgesic responses but has no effect on opioid placebo responses. These findings suggest that the endocannabinoid system has a pivotal role in placebo analgesia in some circumstances when the opioid system is not involved. (via

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Does melatonin do anything at all? Placebo effect, perhaps?


The U.S. Department of Health and Human Services released information today about research on melatonin supplements. The research was conducted at the University of Alberta for the U.S. National Center for Complementary and Alternative medicine. U of A researchers did a comprehensive review of all studies on the use of melatonin supplements to treat sleep disorders.

Click here to read the synopsis of what they found. Not looking so good for melatonin, me thinks!